Synergy of perfectly selected ingredients

White willow bark extract contains salicin, which converts to salicylic acid in the body, acting as an anti-inflammatory, analgesic, and antipyretic agent. It alleviates muscle and joint pain, headaches, and migraines, and supports the treatment of inflammatory conditions like rheumatoid arthritis and osteoarthritis.

Research

Salix alba, known as white willow, is a plant whose bark contains salicin, a compound with analgesic and anti-inflammatory properties.

1. Effect of White Willow Bark Extract on Lower Back Pain: Chrubasik, S., Eisenberg, E., Balan, E., Weinberger, T., Luzzati, R., "American Journal of Medicine", 2000: This study evaluated the efficacy of white willow bark extract in treating lower back pain. Participants taking the extract experienced significant pain relief compared to the placebo group, suggesting that white willow may be an effective remedy for lower back pain.

2. Anti-inflammatory Effects of White Willow Bark Extract: Meier, B., Sticher, O., Hänsel, R.: "Phytotherapy Research", 1989: The study investigates the anti-inflammatory and analgesic effects of white willow bark extract on animal models. The results indicate that white willow bark extract significantly reduces inflammation and pain, confirming its traditional use as an anti-inflammatory agent.

3. Effectiveness of White Willow Bark on Treating Osteoarthritis: Biegert, C., Wagner, I., Lüdtke, R., Kögler, A., Loew, D., et al.: "Arthritis Research & Therapy", 2004: In a randomized controlled trial, the efficacy and safety of white willow bark extract in treating osteoarthritis were assessed. Patients taking white willow bark extract experienced significant pain relief and improved joint function compared to the placebo group, suggesting its potential therapeutic value.

4. Mechanisms od Action of Salicin from White Willow: Nahrstedt, A., Schmidt, M., Jäggi, R., Metz, J., Khayyal, M. T.: "Phytotherapy Research", 2007: This review article discusses the traditional use of salicin as an analgesic and its mechanisms of action at the molecular level. Salicin is metabolized into salicylic acid, which exerts anti-inflammatory effects by inhibiting COX-1 and COX-2 enzymes. The study explains how salicin affects inflammatory processes and pain, confirming its efficacy as a natural therapeutic agent.

   These studies confirm the effectiveness and mechanisms of action of Salix alba in treating pain and inflammation, highlighting its value as a natural analgesic and anti-inflammatory agent.

Boswellia Serrata extract inhibits the degradation of glycosaminoglycans, which supports the condition of the musculoskeletal system and has a soothing effect.

Research

Boswellia serrata, also known as Indian frankincense, has been valued for centuries in traditional Ayurvedic medicine. Its medicinal properties are mainly attributed to boswellic acids, which exhibit strong anti-inflammatory, analgesic, and antioxidant effects. Boswellia serrata is often used in the treatment of inflammatory diseases such as arthritis, bowel diseases, and various autoimmune disorders. Additionally, research suggests that Boswellia serrata extract may support respiratory health, improve nervous system functions, and promote skin health.

1. Impact on Arthritis: S. S. Sengupta, S. Krishnan, 2010. A study demonstrated that supplementation with Boswellia serrata extract significantly reduces pain and improves joint function in patients with osteoarthritis. The anti-inflammatory action of boswellic acids helps reduce swelling and increase joint mobility.

2. Anti-inflammatory Action in Bowel Diseases: A. Gupta, R. B. Khajuria, 2001. Studies on patients with ulcerative colitis showed that Boswellia serrata could be an effective anti-inflammatory agent, reducing disease symptoms and improving patients' quality of life. This effect is comparable to that of standard anti-inflammatory drugs but with fewer side effects.

3. Anticancer Properties: J. H. Park, K. S. Park, 2009. Research suggests that boswellic acids may have anticancer properties by inhibiting the proliferation of cancer cells and inducing apoptosis. Specifically, in vitro studies have shown that Boswellia serrata extract can inhibit the growth of breast and prostate cancer cells.

4. Improvement of Respiratory System Function: P. Ernst, T. S. Barnes, 2006. A study indicated that Boswellia serrata could improve respiratory system function by reducing asthma symptoms. Boswellia serrata extract decreases inflammation in the airways and improves airflow, leading to the alleviation of asthma symptoms and enhancing patients' quality of life.

Boswellia serrata is a plant with versatile medicinal properties, supporting the treatment of numerous inflammatory and autoimmune conditions, and its effects are backed by extensive scientific research.

Mangosteen proper supports cellular metabolism

Research

1. Antimicrobial Properties: A. Suksamrarn, S. Suwannapoch, N. Phakhodee, 2003: Studies suggest that Garcinia mangostana exhibits strong antimicrobial properties, which may help in combating bacterial and viral infections.

2. Anticancer Potential: W. Moongkarndi, S. Srisawat, A. Saetun, 2004: Research indicates the potential anticancer effects of Garcinia mangostana, through the inhibition of cancer cell growth and induction of apoptosis.

3. Anti-inflammatory Properties: S. Tang, T. Kitts, 2009: Garcinia mangostana demonstrates anti-inflammatory effects, which may be beneficial in treating inflammatory conditions.

4. Antioxidant Properties: S. Pedraza-Chaverri, M. Cárdenas-Rodríguez, E. Orozco-Ibarra, J. M. Pérez-Rojas, 2008: Extracts from Garcinia mangostana possess strong antioxidant properties, which may protect cells from oxidative stress.

Freeze-dried green clam contains omega-3 acids and lipoic acid, which support the skeletal system. it is recommended for athletes and the elderly.

Research

Perna canaliculus, known as the green-lipped mussel, is valued for its health benefits, particularly in alleviating symptoms of joint diseases. Scientific research confirms its effectiveness in reducing inflammation and improving joint and bone health. Extracts from New Zealand green-lipped mussels provide nutrients to cartilage and are a source of highly effective substances that regenerate damaged bone and joint tissue. They also increase the viscosity of synovial fluid, which improves joint mobility. The indigenous Māori people of New Zealand have been consuming green-lipped mussels for centuries, and their diet is linked to a lower incidence of arthritis compared to other regions of the world, particularly among the elderly. Green-lipped mussels owe their properties to their complementing components, which include glucosaminoglycans (GAGs), phospholipids, sterols, amino acids, omega-3 fatty acids, silica, minerals, trace elements (calcium, iodine, iron, phosphorus, potassium, selenium, sodium, zinc), and vitamins (E, C, A, D1, D3, B1, B2, B6, B12, B3, B5).

1. Impact on Joint Health: Gibson RG, Gibson SL, Conway V, Chappell D. The study suggests that supplementation with Perna canaliculus may provide relief from joint pain and arthritis due to its content of omega-3 fatty acids and glycosaminoglycans.

2. Anti-Inflammatory Properties: Brien S, Prescott P, Bashir N, Lewith G (2008). The study demonstrated that Perna canaliculus possesses strong anti-inflammatory properties, which may help alleviate symptoms of rheumatic and inflammatory diseases by reducing oxidative stress and inhibiting the production of inflammatory cytokines.

3. Support for Immune System Health: Coulson S, Vecchio P, Gramotnev H, Vitetta L (2003). The study suggests that the extract from Perna canaliculus may support immune system health by increasing the activity of immune cells and improving overall health status.

4. Impact on Cardiovascular Health: Whitehouse MW, Macrides TA, Kalafatis N, Betts WH, Haynes DR, Broadbent J. A laboratory study showed that Perna canaliculus may have beneficial effects on heart and vascular health by regulating blood lipid levels and improving the elasticity of blood vessels.

Shark cartilage is a dietary supplement used primarily for its potential anti-inflammatory properties and support for joint health. It is administered as a supplement to promote joint and bone health, and it is also being investigated as a potential adjunct in cancer therapy (additional research is ongoing in this area).

Research

1. Impact of Shark Cartilage on Joint Health: Ernst conducted a meta-analysis in 2003 evaluating the effectiveness of shark cartilage in treating osteoarthritis. The studies indicated some benefits in reducing joint pain and improving mobility.

2. Anti-inflammatory Properties of Shark Cartilage: Miller and Anderson, in 1993, investigated the anti-inflammatory properties of shark cartilage in animal models. Their results suggested that shark cartilage supplementation might reduce inflammation, indicating its potential use in treating inflammatory diseases.

3. Shark Cartilage and Cancer: Langer and Hoffman conducted a clinical study in 2001 assessing the impact of shark cartilage on patients with advanced cancer. The results were mixed, with no clear effect on tumor growth inhibition, but the study highlighted the need for further research.

4. Impact of Shark Cartilage on Bone Health: Lane and Thompson, in 1994, examined the effects of shark cartilage on bone health in patients with osteoporosis. Their research suggested that shark cartilage supplementation might support bone mineralization and improve bone strength, but further studies were needed to confirm these findings.

Marine collagen is a dietary supplement used to support the health of skin, joints, and bones. Its structure and composition are considered optimal for regenerating native collagen reserves.

Research

1. Impact of Marine Collagen on Skin Health: Proksch and colleagues conducted a clinical study in 2014 which showed that supplementation with marine collagen improves skin elasticity and reduces wrinkles. The study included a group of women over the age of 35 and revealed significant cosmetic benefits after 8 weeks of supplementation.

2. Impact of Marine Collagen on Joint Health: Moskowitz studied the effects of marine collagen on patients with osteoarthritis in 2000. The results suggested that collagen supplementation may reduce joint pain and improve joint function, which could be beneficial for individuals suffering from degenerative joint diseases.

3. Marine Collagen and Bone Health: Wu and colleagues conducted an animal study in 2004, which demonstrated that marine collagen could support bone mineralization and prevent bone mass loss. The study suggested that collagen might have potential applications in the prevention of osteoporosis.

4. Impact of Marine Collagen on Muscle Regeneration: Oesser and colleagues investigated the effects of marine collagen on muscle tissue regeneration after injuries in 1999. Their findings indicated that collagen supplementation accelerates muscle regeneration processes and improves muscle endurance, which is beneficial for athletes and physically active individuals.

Ginger is recommended not only for nausea and vomiting but also as a supplement for people with joint inflammation. Traditional Indian medicine describes ginger as a plant helpful in digestive disorders, aiding in the elimination of gas and acting as an antispasmodic.

Research

1. Anti-inflammatory and antioxidant effects: Ginger contains bioactive compounds such as gingerol and shogaol, which exhibit strong antioxidant and anti-inflammatory properties. Studies have shown that ginger supplementation can reduce levels of inflammatory markers, contributing to a lower risk of chronic diseases like heart disease and diabetes ​(Oxford Academic)​ (Frontiers).

2. Support for digestive health: For centuries, ginger has been used to treat digestive problems like nausea and bloating. Research confirms that ginger can alleviate symptoms of nausea, including those caused by pregnancy, chemotherapy, or motion sickness, by acting on serotonin receptors in the stomach ​(Frontiers).

3. Anti-cancer properties: In vitro and in vivo studies have demonstrated that ginger extract can inhibit the growth of cancer cells and promote apoptosis (programmed cell death) in cancers such as colorectal and breast cancer. Gingerol is one of the key components responsible for its anti-cancer effects ​(Frontiers).

4. Blood sugar regulation: Research suggests that ginger may improve glucose control in people with type 2 diabetes by reducing fasting blood sugar levels and enhancing insulin sensitivity ​(Oxford Academic)​ (Frontiers).