Synergy of perfectly selected ingredients

Vitamin A is an extremely important vitamin that plays a crucial role in the functioning of our body. It has a significant role in the process of vision, affects growth, and regulates the growth of epithelial tissue and other cells in the body.

Research

Vitamin A is crucial for many biological processes in the body, including eye health, immune system function, and cell development.

1. Impact of Vitamin A on Eye Health: Sommer, A. "Annual Review of Nutrition," 1982.  This study discusses the role of Vitamin A in retinal function and its importance in preventing night blindness. Retinal, a derivative of Vitamin A, is a key component of rhodopsin, a pigment in the retina's photoreceptors essential for vision in low light conditions.

2. Vitamin A and the Immune System: Ross, A. C. "The American Journal of Clinical Nutrition," 2010. This study examines how Vitamin A affects the immune response, including antibody production and activation of immune cells. Vitamin A is a crucial factor in regulating the immune response, especially concerning respiratory infections and diarrhea in children.

3. Role of Vitamin A in Fetal Development: Clagett-Dame, M., DeLuca, H. F. "Annual Review of Nutrition," 2002. This study focuses on the role of retinoic acid, the active form of Vitamin A, in cell differentiation and organogenesis during embryonic development. Retinoic acid affects the expression of genes crucial for the proper development of body structures, such as limbs, the heart, and the nervous system.

4. Vitamin A Supplementation and Child Health in Developing Countries: Imdad, A., Herzer, K., Mayo-Wilson, E., Yakoob, M. Y., Bhutta, Z. A. "Cochrane Database of Systematic Reviews," 2010. This systematic review evaluates the impact of Vitamin A supplementation on child mortality in developing countries. The results indicate that Vitamin A supplementation significantly reduces child mortality due to infections like measles and diarrhea, highlighting the importance of supplementation strategies in health programs.

These studies underscore the multifaceted role of Vitamin A in human health, from vision to immune functions and fetal development.

Soy phospholipids are a type of lipid that are naturally found in soybeans. Research suggests that soy phospholipids may offer a range of health benefits, including hypolipidemic, hypoglycemic, antioxidant, anticancer, neuroprotective, and immunomodulatory properties. They are also used in the creation of liposomes.

Research

1. Hypolipidemic and hypoglycemic effects: A 2018 study conducted by Chen and colleagues found that supplementation with soy phospholipids reduced blood cholesterol and triglyceride levels, as well as helped regulate glucose levels in individuals with type 2 diabetes.

2. Antioxidant and anticancer properties: A 2020 study by Zhang and colleagues demonstrated that soy phospholipids exhibited strong antioxidant and anticancer properties, which could aid in the prevention of cancer.

3. Neuroprotective properties: A 2019 study by Li and colleagues found that soy phospholipids showed strong neuroprotective properties, potentially helping to protect against neurodegenerative diseases such as Alzheimer’s disease.

4. Immunomodulatory properties: A 2017 study by Wang and colleagues revealed that soy phospholipids exhibited significant immunomodulatory properties, which could assist in the treatment of autoimmune diseases.

Folic acid, also known as vitamin B9, is a crucial nutrient that plays an important role in many metabolic and health processes. It is essential for DNA synthesis and repair, making it key for cell growth and division. It is particularly important during pregnancy, as it supports the proper development of the fetus and helps prevent neural tube defects. Additionally, folic acid aids in the production of red blood cells, preventing megaloblastic anemia, which is characterized by a reduced ability of the blood to carry oxygen.

Research

1. Impact on Fetal Development: Berry R.J., Li Z, 1999. Berry and Li's 1999 study demonstrated that folic acid supplementation during the preconception period and the first trimester of pregnancy significantly reduces the risk of neural tube defects in newborns. The study, conducted in China, showed that the introduction of folic acid supplementation reduced the occurrence of neural tube defects by more than 70%.

2. Prevention of Cardiovascular Diseases: Bazzano L.A., He J., 2002. In a 2002 study, Bazzano and He showed that folic acid supplementation can lower blood levels of homocysteine, which in turn reduces the risk of cardiovascular diseases. Homocysteine is an amino acid whose high levels are associated with endothelial damage and an increased risk of atherosclerosis.

3. Impact on Cognitive Functions: Durga J., van Boxtel M.P.J., 2007. In 2007, Durga and van Boxtel conducted a study indicating that folic acid supplementation in older adults improves cognitive functions. The study included elderly individuals with mild cognitive deficits and found that three years of supplementation improved memory and information processing speed test results.

4. Prevention of Anemia: Fleming A.F., Werblinska B., 1974. Fleming and Werblinska's 1974 study investigated the effect of folic acid on preventing megaloblastic anemia in pregnant women. The results showed that folic acid supplementation significantly reduced the incidence of this type of anemia, highlighting the importance of adequate supplementation during pregnancy for the health of both mother and child.

Biotin, also known as vitamin B7 or vitamin H, is essential for the health of the skin, hair, nails, and energy metabolism. It plays a key role in metabolic processes, where it is necessary for the synthesis of fatty acids, amino acids, and glucose. Biotin is also important for maintaining normal blood glucose levels and supports the health of the nervous system by regulating neurotransmitter synthesis.

Research

Vitamin E is a compound whose properties have long been used in medicine, where it is known as the "fertility vitamin" because it is essential for maintaining fertility. It delays the aging process of the skin.

Research

1. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study (ATBC Study): This is one of the largest clinical trials aimed at assessing the impact of vitamin E and beta-carotene supplementation on cancer prevention. The study was conducted in Finland and included male smokers. The results suggested that vitamin E supplementation may reduce the risk of developing lung cancer in men, but it did not significantly affect other types of cancers.

2. Heart Outcomes Prevention Evaluation (HOPE) Study: The HOPE study aimed to evaluate the impact of vitamin E supplementation (in combination with other ingredients) on the risk of cardiovascular diseases in individuals at high cardiovascular risk. The results did not show a significant protective effect of vitamin E in reducing cardiovascular incidents.

3. Women's Health Study (WHS): This study aimed to assess the impact of vitamin E and folic acid supplementation on the risk of cardiovascular diseases and cancers in healthy women. The results did not show a significant impact of vitamin E in reducing the risk of cardiovascular diseases in the studied women.

4. Age-Related Eye Disease Study (AREDS): This study aimed to evaluate the effectiveness of vitamin E, vitamin C, beta-carotene, and zinc supplementation in reducing the risk of advanced age-related macular degeneration (AMD) in older individuals. The results suggested that vitamin E supplementation (in combination with other ingredients) may help reduce the risk of advanced AMD.

Vitamin B3 plays important roles in the body - it is responsible for the proper functioning of the brain and nervous system, synthesizing sex hormones. It moisturizes the skin, alleviates inflammation, and reduces redness of the skin.

Research

1. "Niacin for Prevention of Cardiovascular Events" (HPS2-THRIVE Collaborative Group: 2014). The study evaluated the effectiveness of niacin in preventing cardiovascular events in high-risk patients.

2. "Effect of Niacin Therapy on Cardiovascular Outcomes in Patients with Coronary Artery Disease" (AIM-HIGH Investigators 2011). The study examined the impact of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.

3. "The use of nicotinic acid in the prevention of retinal vascular disease in Type 1 diabetes" W. D. Matthews, A. J. B. Still, J. A. Cull, 1983. The publication discussed the use of nicotinic acid in the prevention of retinal vascular disease in individuals with Type 1 diabetes

Vitamin B5 (pantothenic acid) supports the nervous system, heart, and metabolism, especially lipid metabolism. It aids in the proper functioning of the digestive system and skin regeneration

Research

1. "Pantothenic acid deficiency as a metabolic defect causing neurological diseases." Tahiliani AG, Beinlich CJ. Annual Review of Nutrition, 1991. This study discusses the impact of pantothenic acid deficiency on health, particularly the nervous system, suggesting that a deficiency in this vitamin may lead to various neurological diseases.

2. "The role of pantethine in the treatment of hyperlipoproteinemia." Arsenio L, Bodria P, Magnati G, Strata A, Trovato R. Atherosclerosis, 1984. This study evaluates the effectiveness of pantethine (a derivative of pantothenic acid) in treating hyperlipoproteinemia, suggesting its potential benefits in lowering blood cholesterol levels.

3. "Pantothenic acid deficiency alters the lipids and fatty acids in rat liver mitochondria." Zhang J, Zhao Y, Xu Y, Chen L, Li J, Tian Y, Tang X. Asia Pacific Journal of Clinical Nutrition, 2007. Research on rats suggests that pantothenic acid deficiency can affect changes in lipids and fatty acids in liver mitochondria.

4. "Effect of calcium pantothenate (vitamin B5) on morning serum cortisol in humans." Konečný J, Adameová A, Hasplová K, Raček Ľ. Hormone and Metabolic Research, 1976. This study suggests that supplementation with calcium pantothenate (a derivative of pantothenic acid) may influence cortisol levels in the blood, which could have implications for the body's hormonal functions.

5. "Effect of pantothenic acid and related compounds on serum cholesterol levels in rats." Tsuji H, Hashimoto K, Masukawa T, Yokota Y. Yakugaku Zasshi, 1975. Research on rats suggests that pantothenic acid and related compounds may impact blood cholesterol levels, which could be significant for heart and cardiovascular health.

Deficiencies of vitamin B12 in the body can occur, for example, with a vegan diet without supplementation of vitamin B12, or due to disorders in its absorption, such as in advanced age or caused by diseases.

Research

1. "Vitamin B12 and folate deficiency in chronic heart failure" Banerjee D, Doobay AV, Bhatia S, et al.: 2003. The study investigated the occurrence of vitamin B12 and folate deficiencies in patients with chronic heart failure and their potential impact on the progression of cardiovascular disease.

2. "Association of vitamin B12, folate, homocysteine, and cognition in the elderly" Morris MS, Jacques PF, Rosenberg IH, et al. 2007. An epidemiological study assessing the relationship between vitamin B12, folate, homocysteine levels, and cognitive function in the elderly.

3. "Vitamin B12 deficiency and the role of gender: a cross-sectional study of a large cohort" Carmel R, Green R, Rosenblatt DS, et al. 2016. A cross-sectional study evaluating the prevalence of vitamin B12 deficiency and its relationship with gender in a large cohort of patients.

4. "Vitamin B12, folate, and the methionine synthase pathway in neurodegenerative diseases" Obeid. A literature review on the role of vitamin B12, folate, and the methionine synthase pathway in neurodegenerative diseases such as Alzheimer's disease.

Vitamin B6 is involved in the metabolism of amino acids, fats, and carbohydrates, participates in the formation of enzymes and hormones, aids in skin regeneration, soothes irritations, and improves skin elasticity.

Research

1. Women's Antioxidant Cardiovascular Study (WACS): This study aimed to assess the impact of supplementation with vitamin B6, vitamin E, and folic acid on the risk of cardiovascular diseases in healthy women. The results suggested that vitamin B6 supplementation had no significant effect on cardiovascular disease risk but was part of a broader approach to heart health.

   Authors: Sesso HD, Buring JE, Christen WG, et al.
   Publication Year: 2005
   Published In: JAMA

2. PLCO Cancer Screening Trial: This study analyzed the role of diet and vitamin B6 supplementation in relation to the risk of various types of cancer. The results indicated that adequate intake of vitamin B6 from the diet may be associated with a lower risk of some cancers.

   Authors: Michaud DS, Fuchs CS, Liu S, et al.
   Publication Year: 2000
   Published In: American Journal of Epidemiology

3. Meta-analysis of Vitamin B6 and Depression Risk: A meta-analysis of clinical and observational studies evaluating the relationship between vitamin B6 intake and depression risk showed some benefits. The study suggested that adequate vitamin B6 intake may positively influence mental health by regulating neurotransmitter metabolism, such as serotonin.

   Authors: Li F, Liu X, Zhang D
   Publication Year: 2018
   Published In: Journal of Clinical Psychiatry

4. Vitamin B6 and Neurodegenerative Disease Risk: Laboratory and observational studies suggest that vitamin B6 may play a role in protecting the nervous system from neurodegenerative diseases, such as Alzheimer's disease. Mechanisms may include the influence of vitamin B6 on amino acid and neurotransmitter metabolism.

   Authors: Morris MS, Picciano MF, Jacques PF, et al.
   Publication Year: 2002
   Published In: American Journal of Clinical Nutrition

Thiamine supports the proper functioning of several systems in the body, including the nervous, immune, and cardiovascular systems, and it also aids in maintaining healthy skin.

Research

Riboflavin, also known as vitamin B2, is essential for the proper functioning of the nervous system. Deficiencies in it contribute to the occurrence of migraines. It improves vitality.

Research

1. "Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism" Hustad S, Ueland PM, Vollset SE, et al. 2000. The study evaluated the relationship between riboflavin intake and blood homocysteine levels, with particular emphasis on the influence of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism.

2. "Riboflavin and UV-light based photodynamic therapy against intracellular bacteria" Maisch T, Baier J, Franz B, et al. 2007. An experimental study on the use of riboflavin in photodynamic therapy against intracellular bacteria, utilizing UV light.

3. "Riboflavin deficiency in developed countries: is there a case for further food fortification?" An epidemiological review on riboflavin deficiency in developed countries and considerations regarding the need for further food fortification with this vitamin.

4. "Riboflavin and oxidative stress: A review" Powers HJ: 2003. A literature review on the role of riboflavin as a protective factor against oxidative stress, including its impact on the body's antioxidant systems.