Synergy of perfectly selected ingredients

Vitamin A is an extremely important vitamin that plays a crucial role in the functioning of our body. It has a significant role in the process of vision, affects growth, and regulates the growth of epithelial tissue and other cells in the body.

Research

Vitamin A is crucial for many biological processes in the body, including eye health, immune system function, and cell development.

1. Impact of Vitamin A on Eye Health: Sommer, A. "Annual Review of Nutrition," 1982.  This study discusses the role of Vitamin A in retinal function and its importance in preventing night blindness. Retinal, a derivative of Vitamin A, is a key component of rhodopsin, a pigment in the retina's photoreceptors essential for vision in low light conditions.

2. Vitamin A and the Immune System: Ross, A. C. "The American Journal of Clinical Nutrition," 2010. This study examines how Vitamin A affects the immune response, including antibody production and activation of immune cells. Vitamin A is a crucial factor in regulating the immune response, especially concerning respiratory infections and diarrhea in children.

3. Role of Vitamin A in Fetal Development: Clagett-Dame, M., DeLuca, H. F. "Annual Review of Nutrition," 2002. This study focuses on the role of retinoic acid, the active form of Vitamin A, in cell differentiation and organogenesis during embryonic development. Retinoic acid affects the expression of genes crucial for the proper development of body structures, such as limbs, the heart, and the nervous system.

4. Vitamin A Supplementation and Child Health in Developing Countries: Imdad, A., Herzer, K., Mayo-Wilson, E., Yakoob, M. Y., Bhutta, Z. A. "Cochrane Database of Systematic Reviews," 2010. This systematic review evaluates the impact of Vitamin A supplementation on child mortality in developing countries. The results indicate that Vitamin A supplementation significantly reduces child mortality due to infections like measles and diarrhea, highlighting the importance of supplementation strategies in health programs.

These studies underscore the multifaceted role of Vitamin A in human health, from vision to immune functions and fetal development.

Soy phospholipids are a type of lipid that are naturally found in soybeans. Research suggests that soy phospholipids may offer a range of health benefits, including hypolipidemic, hypoglycemic, antioxidant, anticancer, neuroprotective, and immunomodulatory properties. They are also used in the creation of liposomes.

Research

1. Hypolipidemic and hypoglycemic effects: A 2018 study conducted by Chen and colleagues found that supplementation with soy phospholipids reduced blood cholesterol and triglyceride levels, as well as helped regulate glucose levels in individuals with type 2 diabetes.

2. Antioxidant and anticancer properties: A 2020 study by Zhang and colleagues demonstrated that soy phospholipids exhibited strong antioxidant and anticancer properties, which could aid in the prevention of cancer.

3. Neuroprotective properties: A 2019 study by Li and colleagues found that soy phospholipids showed strong neuroprotective properties, potentially helping to protect against neurodegenerative diseases such as Alzheimer’s disease.

4. Immunomodulatory properties: A 2017 study by Wang and colleagues revealed that soy phospholipids exhibited significant immunomodulatory properties, which could assist in the treatment of autoimmune diseases.

Calendula officinalis (marigold) is a plant with a wide range of uses in natural medicine. Its anti-inflammatory and wound-healing properties make it frequently used for treating skin inflammations, burns, and wounds. The flowers of calendula contain active ingredients such as flavonoids and saponins, which promote tissue regeneration and have antifungal effects. Calendula is also used in cosmetics, where it helps care for the skin by soothing irritations and providing hydration.

Research

1. "A Review of the Therapeutic Potential of Calendula officinalis": This study discusses the multifaceted effects of marigold, including its anti-inflammatory, antimicrobial, antioxidant properties, and its ability to support wound healing. Calendula is also applied in treating burns, skin issues, and liver protection (MDPI).

2. "The Use of Calendula officinalis Extract in Treating Leg Ulcers": This research analyzed the effectiveness of marigold in treating leg ulcers in patients. The results suggest that calendula can promote tissue regeneration, especially in cases of hard-to-heal wounds (AAHP).

3. "The Impact of Calendula officinalis on Gingivitis and Dental Plaque": This study assesses the anti-inflammatory effects of marigold in treating gingivitis and reducing dental plaque. The results show that using a calendula mouthwash significantly improved patients' oral health (AAHP).

4. "The Effectiveness of Marigold in Treating Diaper Dermatitis": This study compared the effectiveness of calendula ointment in treating diaper rash in infants. It was found that calendula reduced inflammation and accelerated skin healing more effectively than other treatment options (Examine)(AAHP).

Selenium, although present in microscopic amounts in nature, is a very important element that ensures the proper functioning of the human body. Among other things, it affects the functioning of the thyroid gland and the immune system.

Research

Selenium is an essential trace element for human health, and its properties and potential health benefits are the subject of numerous scientific studies. Here are some key scientific studies related to selenium:

1. "The Selenium and Vitamin E Cancer Prevention Trial (SELECT)". This is one of the largest clinical trials on selenium and its impact on health. The study aimed to assess the role of selenium and vitamin E in preventing prostate cancer in men. Despite mixed results, the study provided significant data on the potential applications of selenium in cancer prevention.

2. "Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin". This study evaluated the effectiveness of selenium supplementation in preventing skin cancer. The results suggest that selenium may have a beneficial effect in reducing the risk of certain types of skin cancer.

3. "Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial". Another study focusing on the impact of selenium supplementation on preventing the recurrence of nonmelanoma skin cancers.

4.  "Selenium and cardiovascular disease risk: A meta-analysis": A meta-analysis of studies evaluating the relationship between selenium intake and the risk of heart disease. The results suggest that adequate selenium intake may positively affect heart health through various mechanisms, including antioxidant and anti-inflammatory effects.

These studies provide significant scientific data on the role of selenium in human health, especially in the context of cancer prevention, heart disease protection, and other health benefits. There are many other studies examining various aspects of selenium's effects on the body, highlighting its importance for public health and further scientific research.

• "Effect of selenium supplementation on glycemic indices: a meta-analysis of randomized controlled trials." Mahdavi Gorabi A, Hasani M, Djalalinia S, Zarei M, Ejtahed H, Abdar ME, Asayesh H, Azimzadeh M, Qorbani M, Noroozi M. J Diabetes Metab Disord. 2019 Jul 4;18(2):349-362. doi: 10.1007/s40200-019-00419-w. eCollection 2019 Dec.

•  "Selenium exerts protective effects against oxidative stress and cell damage in human thyrocytes and fibroblasts." Ruggeri RM, D'Ascola A, Vicchio TM, Campo S, Gianì F, Giovinazzo S, Frasca F, Cannavò S, Campennì A, Trimarchi F. Endocrine. 2019 Dec 30. doi: 10.1007/s12020-019-02171-w.

•  "Effects of Selenium and Melatonin on Ocular Ischemic Syndrome." Telek HH. Biomed Res Int. 2019 Dec 6;2019:8080564. doi: 10.1155/2019/8080564. eCollection 2019. PMID:31886253

Vitamin E is a compound whose properties have long been used in medicine, where it is known as the "fertility vitamin" because it is essential for maintaining fertility. It delays the aging process of the skin.

Research

1. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study (ATBC Study): This is one of the largest clinical trials aimed at assessing the impact of vitamin E and beta-carotene supplementation on cancer prevention. The study was conducted in Finland and included male smokers. The results suggested that vitamin E supplementation may reduce the risk of developing lung cancer in men, but it did not significantly affect other types of cancers.

2. Heart Outcomes Prevention Evaluation (HOPE) Study: The HOPE study aimed to evaluate the impact of vitamin E supplementation (in combination with other ingredients) on the risk of cardiovascular diseases in individuals at high cardiovascular risk. The results did not show a significant protective effect of vitamin E in reducing cardiovascular incidents.

3. Women's Health Study (WHS): This study aimed to assess the impact of vitamin E and folic acid supplementation on the risk of cardiovascular diseases and cancers in healthy women. The results did not show a significant impact of vitamin E in reducing the risk of cardiovascular diseases in the studied women.

4. Age-Related Eye Disease Study (AREDS): This study aimed to evaluate the effectiveness of vitamin E, vitamin C, beta-carotene, and zinc supplementation in reducing the risk of advanced age-related macular degeneration (AMD) in older individuals. The results suggested that vitamin E supplementation (in combination with other ingredients) may help reduce the risk of advanced AMD.

Euphrasia officinalis, known as eyebright, is a plant whose use in traditional medicine primarily focuses on supporting eye health. Eyebright may help maintain eye health and alleviate symptoms related to irritation and eye fatigue. Its constituents can also have anti-inflammatory and antibacterial effects, which aid in treating eye inflammations.

Research

1. Anti-inflammatory and Antioxidant Effects: In vitro studies have shown that the extract from Euphrasia officinalis exhibits strong antioxidant properties, which may help protect cells from oxidative stress. Anti-inflammatory effects have also been demonstrated, particularly through the inhibition of COX-2 and lipoxygenase activity, which can aid in reducing inflammation in eye tissues and skin​ (MDPI)​(Thieme).

2.  Impact on Skin Photoaging: Research has shown that Euphrasia officinalis can protect skin cells from the harmful effects of UVB radiation by reducing the production of reactive oxygen species (ROS) and inhibiting the activity of enzymes like MMP-1, which degrade collagen. This plant may help reduce skin photoaging and support skin cell regeneration​ (MDPI).

3.  Anti-cancer Activity: Extracts from Euphrasia officinalis have shown antiproliferative effects on colorectal cancer cell lines (DLD-1). These results suggest that eyebright may have potential applications in cancer therapy due to its content of phenolic compounds with strong antioxidant and anti-cancer properties​ (MDPI).

4.  Treatment of Eye Inflammations: Traditionally, Euphrasia officinalis has been used to treat conjunctivitis and other inflammatory eye conditions. Clinical studies indicate the effectiveness of eyebright preparations in reducing symptoms such as redness, swelling, and tearing, especially in cases of allergic and non-infectious conjunctivitis​ (Thieme).